期刊
DEVELOPMENTAL NEUROSCIENCE
卷 35, 期 2-3, 页码 88-101出版社
KARGER
DOI: 10.1159/000346155
关键词
Caspase-1; Caspase-3; Caspase-8; Inflammation; Apoptosis; Cytokines; Microglia; Inflammasome
资金
- Spanish Ministerio de Ciencia y Tecnologia [SAF2009-13778]
- Proyecto de Excelencia from the Junta de Andalucia [CTS-6494]
- Swedish Research Council
- Parkinson Foundation of Sweden
- Swedish Childhood Cancer Foundation the Swedish Cancer Society
- Michael J. Fox Foundation
Neuroinflammation is a complex immune response against the harmful effects of diverse stimuli within the central nervous system. Caspases are a family of intracellular cysteine proteases that mediate proteolytic events indispensable for transduction of signaling pathway-controlling biological phenomena such as apoptosis and inflammation. To date, 14 players have been identified in mammals. For many years, caspases were simply divided into 'apoptotic' and 'proinflammatory' caspases and this classification remains useful to some extent. However, increasing evidence indicates that many of these so-called apoptotic caspases also exert non-apoptotic functions. In addition, the role of certain members of the supposed inflammatory caspases in the inflammatory process per se has also been discussed. In this review, we highlight the role for 'apoptotic' and 'proinflammatory' caspases in the regulation of the inflammation response with a special focus on the central nervous system. Copyright (c) 2013 S. Karger AG, Basel
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