期刊
DEVELOPMENTAL NEUROSCIENCE
卷 32, 期 3, 页码 163-172出版社
KARGER
DOI: 10.1159/000301135
关键词
Subventricular zone; Telencephalon; Olfactory bulb; Phosphohistone 3; Blood vessels
资金
- Medical Research Council [G0700377]
- Biotechnology and Biological Sciences Research Council [BB/F003285/1]
- NIH [RO1 NS-42253]
- BBSRC [BB/F003285/1] Funding Source: UKRI
- MRC [G0700377] Funding Source: UKRI
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042253] Funding Source: NIH RePORTER
Blood vessels play a critical role in regulating neural stem cell proliferation and migration. We show here that blood vessels became progressively aligned in the direction of the rostral migratory stream (RMS) from embryonic day 14 to postnatal day 4. Dividing cells revealed by phosphohistone H3+ immunoreactivity were statistically closer to isolectin B4+ blood vessels than predicted by chance in the emerging RMS. The close proximity of blood vessels and H3+ cells was consistent regardless of the age of the RMS and was strikingly similar to the embryonic cerebral cortex. In contrast to the adult RMS, we found no evidence for preferential juxtaposition of migratory doublecortin-positive neuroblasts and vasculature in the neonatal RMS. Our work provides an important framework for understanding the precise mechanism behind regulation of proliferation. Copyright (C) 2010 S. Karger AG, Basel
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