期刊
DEVELOPMENTAL NEUROSCIENCE
卷 31, 期 1-2, 页码 36-49出版社
KARGER
DOI: 10.1159/000207492
关键词
Attention-deficit/hyperactivity disorder; Magnetic resonance imaging; Diffusion tensor imaging; Neural systems; Executive function; Attention; Impulsivity; Neuroanatomy
资金
- National Institutes of Mental Health [MH 62152]
- The National Association for Research in Schizophrenia and Depression
- National Institutes of Health National Center for Complementary and Alternative Medicine [PO1AT00204805]
- National Alliance for Research on Schizophrenia and Depression Distinguished Investigator Award
- Janssen Pharmaceuticals
- Johnson
- Johnson Center for the Study of Psychopathology
- Fairway Trust
- The National Center for Research Resources [P41RR14075]
- March of Dimes Foundation
- Mental Illness and Neuroscience Discovery Institute
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [P01AT002048] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR014075] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH062152] Funding Source: NIH RePORTER
Convergent data from neuroimaging, neuropsychological, genetic and neurochemical studies in attention-deficit/hyperactivity disorder (ADHD) have implicated dysfunction of the dorsolateral prefrontal cortex (DLPFC) and dorsal anterior cingulate cortex (dACC), which form the cortical arm of the frontostriatal network supporting executive functions. Furthermore, besides the DLPFC and dACC, structural and functional imaging studies have shown abnormalities in key brain regions within distributed cortical networks supporting attention. The conceptualization of neural systems biology in ADHD aims at the understanding of what organizing principles have been altered during development within the brain of a person with ADHD. Characterizing these neural systems using neuroimaging could be critical for the description of structural endophenotypes, and may provide the capability of in vivo categorization and correlation with behavior and genes. Copyright (C) 2009 S. Karger AG, Basel
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