期刊
DEVELOPMENTAL NEUROSCIENCE
卷 31, 期 6, 页码 523-535出版社
KARGER
DOI: 10.1159/000251907
关键词
Brain damage; Brain hypoxia; Brain injury; Neonatal brain injury; Birth asphyxia; Behavioural outcomes
资金
- National Health and Medical Research Council of Australia
Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys cahirinus) underwent caesarean-section delivery or 7.5 min of asphyxia at 37 days gestational age (term is 39 days). Brain histology was examined at 1 and 7 days of age, and behaviour was evaluated to 28 days of age. Asphyxiated offspring showed significant impairment in non-spatial memory and learning tasks, accompanied by central nervous system inflammation and increased apoptotic cell death but without the presence of large necrotic or cystic lesions. Copyright (C) 2009 S. Karger AG, Basel
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