期刊
DEVELOPMENTAL NEUROPSYCHOLOGY
卷 36, 期 5, 页码 596-613出版社
PSYCHOLOGY PRESS
DOI: 10.1080/87565641.2011.555573
关键词
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资金
- National Institute of Mental Health [R01 MH63442, R01 MH081920]
- Developmental Psychobiology Research Group of the University of Colorado Health Sciences Center (UCHSC), Denver, CO, USA
- USPHS [T32 MH15442, F32 MH78359]
- NATIONAL INSTITUTE OF MENTAL HEALTH [F32MH078359, R01MH063442, R01MH081920, T32MH015442] Funding Source: NIH RePORTER
Patients with psychosis often exhibit abnormalities in basic motor control, but little is known about the neural basis of these deficits. This study examines the neuro-dynamics of movement using magnetoencephalography (MEG) in adolescents with early-onset psychosis and typically developing controls. MEG data were imaged using beamforming then evaluated for task and group effects before, during, and after movement onsets. Primary findings included weaker activation in patients during movement execution in cerebellar cortices. Such aberrations likely contribute to the decreased motor control exhibited by patients with psychosis, and may reflect GABAergic-based inhibitory deficits comparable to those seen in cellular and system-level studies.
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