期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 72, 期 3, 页码 386-394出版社
WILEY-BLACKWELL
DOI: 10.1002/dneu.20913
关键词
habenula; fear; anxiety; helplessness; left-right asymmetry
资金
- Grants-in-Aid for Scientific Research [21700370] Funding Source: KAKEN
The habenula is a part of an evolutionarily highly conserved conduction pathway within the limbic system that connects telencephalic nuclei to the brain stem nuclei such as interpeduncular nucleus (IPN), the ventral tegmental area (VTA), and the raphe. In mammals, the medial habenula receives inputs from the septohippocampal system, and relaying such information to the IPN. In contrast, the lateral habenula receives inputs from the ventral pallidum, a part of the basal ganglia. The physical adjunction of these two habenular nuclei suggests that the habenula may act asan intersection of the neural circuits for controlling emotion and behavior. We have recently elucidated that zebrafish has the equivalent structure as the mammalian habenula. The transgenic zebrafish, in which the neural signal transmission from the lateral subnucleus of the dorsal habenula to the dorsal IPN was selectively impaired, showed extremely enhanced levels of freezing response to presentation of the conditioned aversive stimulus. Our observation supports that the habenula may act as the multimodal switching board for controlling emotional behaviors and/or memory in experience dependent manners. (c) 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 386394, 2012
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