期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 72, 期 6, 页码 943-952出版社
WILEY-BLACKWELL
DOI: 10.1002/dneu.22009
关键词
neurogenesis; BDNF; cognition; locomotor activity; exercise
资金
- National Institute on Aging, NIH
- EU (NEURAD), HSN, NWO, ISAO
Age-related memory loss is considered to commence at middle-age and coincides with reduced adult hippocampal neurogenesis and neurotrophin levels. Consistent physical activity at midlife may preserve brain-derived neurotrophic factor (BDNF) levels, new cell genesis, and learning. In the present study, 9-month-old female C57Bl/6J mice were housed with or without a running wheel and injected with bromodeoxyuridine (BrdU) to label newborn cells. Morris water maze learning, open field activity and rotarod behavior were tested 1 and 6 months after exercise onset. Here we show that long-term running improved retention of spatial memory and modestly enhanced rotarod performance at 15 months of age. Both hippocampal neurogenesis and mature BDNF peptide levels were elevated after long-term running. Thus, regular exercise from the onset and during middle-age may maintain brain function. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 943952, 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据