期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 71, 期 1, 页码 83-91出版社
WILEY
DOI: 10.1002/dneu.20815
关键词
neuropeptide; GABA; interneuron; cannabinoid; anxiety
资金
- US National Institutes of Health [NS38580]
- American Epilepsy Society
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038580] Funding Source: NIH RePORTER
Cholecystokinin (CCK), a peptide originally discovered in the gastrointestinal tract, is one of the most abundant and widely distributed neuropeptides in the brain. In spite of its abundance, recent data indicate that CCK modulates intrinsic neuronal excitability and synaptic transmission in a surprisingly cell-type specific manner, acting as a key molecular switch to regulate the functional output of neuronal circuits. The central importance of CCK in neuronal networks is also reflected in its involvement in a variety of neuropsychiatric and neurological disorders including panic attacks and epilepsy. (C) 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 83-91, 2011
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