期刊
ACS NANO
卷 9, 期 6, 页码 5646-5656出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn5068094
关键词
hybrid nanogels; pathological responsiveness; ultrasound imaging; magnetic resonance imaging
类别
资金
- National Natural Science Foundation of China [51402215, 21274111, 81371570, 51473123]
- Program for New Century Excellent Talents in University of Ministry of Education of China [NECT-11-0386]
- China Postdoctoral Science Foundation [2014M550245]
- Shanghai Postdoctoral Science Foundation [14R21411200]
- Recruitment Program of Global Experts
A dual-enzyme-loaded multifunctional hybrid nanogel probe (SPIO@GCS/acryl/biotin-CAT/SOD-gel, or SGC) has been developed for dual-modality pathological responsive ultrasound (US) imaging and enhanced T-2-weighted magnetic resonance (MR) imaging. This probe is composed of functionalized superparamagnetic iron oxide particles, a dual enzyme species (catalase and superoxide dismutase), and a polysaccharide cationic polymer glycol chitosan gel. The dual-modality US/MR imaging capabilities of the hybrid nanogel for responsive US imaging and enhanced T-2-weighted MR imaging have been evaluated both in vitro and in vivo. These results show that the hybrid nanogel SGC can exhibit efficient dual-enzyme biocatalysis with pathological species for responsive US imaging. SEC also demonstrates increased accumulation in acidic environments for enhanced T-2-weighted MR imaging. Further research on these nanogel systems may lead to the development of more efficient US/MR contrast agents.
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