期刊
DEVELOPMENTAL DYNAMICS
卷 243, 期 2, 页码 201-215出版社
WILEY
DOI: 10.1002/dvdy.24036
关键词
skeletal muscle growth; muscle atrophy; animal models of muscle wasting; proteostasis
资金
- Muscular Dystrophy Association
- NIH [AR055255, R01AR057352]
- Italian Association for Cancer Research AIRC-Start Up [11423]
- St. Jude Children's Hospital/ALSAC
- Ellison Medical Foundation - New Scholar in Aging Award
- HHMI
Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. Results: In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting. Conclusions: Studies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans. Developmental Dynamics 243:201-215, 2014. (c) 2013 Wiley Periodicals, Inc.
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