期刊
DEVELOPMENTAL DYNAMICS
卷 241, 期 4, 页码 675-683出版社
WILEY
DOI: 10.1002/dvdy.23750
关键词
Shh; mouse; disc; nucleus pulposus; chick
资金
- National Institutes of Health/National Institute on Aging [AG029353]
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR055568]
- HHMI
- University of Florida
Deterioration of the intervertebral discs is an unfortunate consequence of aging. The intervertebral disc in mammals is composed of three parts: a jelly-like center called the nucleus pulposus, the cartilaginous annulus fibrosus, and anterior and posterior endplates that attach the discs to vertebrae. To understand the origin of the disc, we have investigated the intervertebral region of chickens. Surprisingly, our comparison of mouse and chicken discs revealed that chicken discs lack nuclei pulposi. In addition, the notochord, which in mice forms nuclei pulposi, was found to persist as a rod-like structure and express Shh throughout chicken embryogenesis. Our fate mapping data indicate that cells originating from the rostral half of each somite are responsible for forming the avian disc while cells in the caudal region of each somite form vertebrae. A histological analysis of mammalian and nonmammalian organisms suggests that nuclei pulposi are only present in mammals. Developmental Dynamics 241:675683, 2012. (C) 2012 Wiley Periodicals, Inc.
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