期刊
DEVELOPMENTAL DYNAMICS
卷 240, 期 10, 页码 2354-2363出版社
WILEY-BLACKWELL
DOI: 10.1002/dvdy.22727
关键词
Brn genes; neurogenesis; tectum development; teleost; neural progenitors; proliferation
资金
- INRA
- INSERM
- University of Paris-Sud
- CNRS
- Plurigenes STREP project [LSHG-CT-2005-01867]
- European Commission [STREP FP7 CISSTEM]
The highly conserved POU genes encode homeodomain transcription factors involved in various developmental events, with some, the Brn genes, playing key roles in neurogenesis. We investigated the evolutionary relationships between these genes, by studying the POU gene complement of a model teleost, the medaka (Oryzias latipes). We identified 17 POU genes and carried out a comprehensive in situ hybridization analysis focusing on the optic tectum, a cortical structure of the mesencephalon, in which cell positions and their differentiation states are spatially and temporally correlated. Six POU genes displayed patterned expression in the optic tectum: two genes were expressed in the center of the organ (a zone with differentiated neurons), two in an intermediate zone in which cells exit the cell cycle and two in the peripheral proliferation zone. These results suggest that POU genes may play key roles in both late neurogenesis and in multipotent neural progenitors. Developmental Dynamics 240:2354-2363, 2011. (C) 2011 Wiley-Liss, Inc.
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