期刊
DEVELOPMENTAL DYNAMICS
卷 240, 期 2, 页码 324-332出版社
WILEY
DOI: 10.1002/dvdy.22525
关键词
Notch; Trio; Rac; Abl; axon guidance; Drosophila
资金
- NIH [NINDS: Z01NS003013]
The receptor Notch interacts with the Abl tyrosine kinase signaling pathway to control axon growth and guidance in Drosophila motor neurons. In part, this is mediated by binding to Trio, a guanine nucleotide exchange factor (GEF) for Rho GTPases. We show here that one of the two GEF domains of Trio, the Rac-specific GEF1, is essential for Trio-dependent motor axon guidance and for the genetic suppression of Notch function in motor axon patterning, but the Rho-specific GEF2 domain is not. Consistent with this, we show that Rac, and not Rho1 or Cdc42, interacts genetically with Notch in a manner indistinguishable from that of bona fide Abl signaling components. We infer, therefore, that Rac is a key component of Abl signaling in Drosophila motor axons, and specifically that it is the crucial Rho GTPase in noncanonical Notch/Abl signaling. Developmental Dynamics 240:324-332, 2011. (C) 2011 Wiley-Liss, Inc.
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