期刊
DEVELOPMENTAL DYNAMICS
卷 240, 期 2, 页码 394-403出版社
WILEY
DOI: 10.1002/dvdy.22528
关键词
Translocon-associated protein complex gamma; subunit (Trap-gamma); signal sequence receptor 3 (Ssr3); placenta; vascular network formation; mouse
资金
- Ministry of Education, Science, Sports and Culture of Japan [20200071, 20057021, 21028016, 22770220]
- Japan Society for Promotion of Science
- Grants-in-Aid for Scientific Research [22770220, 20057021, 20200071, 21028016] Funding Source: KAKEN
The translocon-associated protein (TRAP, also termed the signal sequence receptor) complex is required for the efficient translocation of secretory and membrane proteins in the endoplasmic reticulum, and is also involved in the endoplasmic reticulum stress-mediated unfolded protein response pathway. To investigate the roles of Trap-gamma, a TRAP complex subunit, we generated Trap-gamma knockout mice and found that mutant pups died soon after birth because of retarded embryonic organ growth, especially in the lung. The mutant placentae showed severe vascular network malformation in the labyrinth and significant reductions in blood space areas, which had an adverse effect on intrauterine embryonic growth. Placental malformation was already found by the mid-gestation-stage mutant placenta, with poor vascular endothelial cell proliferation in the chorionic plate region and increased apoptotic cell death in the labyrinth. Thus, Trap-gamma appears to be required for vascular network formation in murine placental development. Developmental Dynamics 240:394-403, 2011. (C) 2011 Wiley-Liss, Inc.
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