期刊
DEVELOPMENTAL DYNAMICS
卷 239, 期 7, 页码 2102-2109出版社
WILEY
DOI: 10.1002/dvdy.22336
关键词
Gpr177; Wntless; Evi; Sprinter; beta-catenin; Wnt production; Wnt signaling; organogenesis
资金
- National Institutes of Health [CA106308, DE015654]
Wls/Evi/Srt encoding a multipass transmembrane protein has been identified as a regulator for proper sorting and secretion of Wnt in flies. We have previously demonstrated that Gpr177 is the mouse ortholog required for axis determination. Gpr177 is a transcriptional target of Wnt that is activated to assist its subcellular distribution in a feedback regulatory loop. We, therefore, proposed that reciprocal regulation of Wnt and Gpr177 is essential for the Wnt-dependent developmental and pathogenic processes. Here, we examine the expression pattern of Gpr177 in mouse development. Gpr177 is expressed in a variety of tissues and cell types during organogenesis. Furthermore, Gpr177 is a glycoprotein primarily accumulating in the Golgi apparatus in signal-producing cells. The glycosylation of Gpr177 is necessary for proper transportation in the secretory pathway. Our findings suggest that the Gpr177-mediated regulation of Wnt is crucial for organogenesis in health and disease. Developmental Dynamics 239:2102-2109, 2010. (C) 2010 Wiley-Liss, Inc.
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