期刊
DEVELOPMENTAL DYNAMICS
卷 240, 期 1, 页码 135-148出版社
WILEY
DOI: 10.1002/dvdy.22515
关键词
Drosophila visual system; photoreceptor axon guidance; growth cone cytoskeleton
资金
- Max Planck Society
- Deutsche Forschungsgemeinschaft (DFG)
Neurons steer their axons towards their proper targets during development. Molecularly, a number of guidance receptors have been identified. The transmembrane protein Golden goal (Gogo) was reported previously to guide photoreceptor (R) axons in the Drosophila visual system. Here, we show that Hts, the Drosophila homologue of Adducin, physically interacts with Gogo's cytoplasmic domain via its head-neck domain. hts null mutants show similar defects in R axon guidance as do gogo mutants. Rescue experiments suggest that the C-terminal tail but not the MARCKS homology domain of Hts is required. Overexpression of either gogo or hts causes abnormally thick swellings of R8 axons in the medulla, but if both are co-overexpressed, R8 axons appear normal and the amount of excessive Hts is reduced. Our results fit with a model where Gogo both positively and negatively regulates Hts that affects the Actin-Spectrin cytoskeleton in growth cone filopodia, thereby guiding R axons. Developmental Dynamics 240: 135-148, 2011. (C) 2010 Wiley-Liss, Inc.
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