期刊
DEVELOPMENTAL DYNAMICS
卷 238, 期 3, 页码 766-774出版社
WILEY
DOI: 10.1002/dvdy.21882
关键词
fracture repair; FGF; fibroblast growth factor; endochondral ossification; fracture healing
资金
- NIAMS NIH HHS [R01 AR036994] Funding Source: Medline
- NICHD NIH HHS [HD049808, R01 HD049808-03, R01 HD049808] Funding Source: Medline
Fibroblast growth factors (FGFs) are important signaling molecules that regulate many stages of endochondral bone development. During the healing of a skeletal fracture, several features of endochondral bone development are reactivated. To better understand the role of FGFs in skeletal fracture healing, we quantitatively evaluated the temporal expression patterns of Fgfs, Fgf receptors (Fgfrs), and molecular markers of bone development over a 14-day period following long bone fracture in a mouse model. These studies identify distinct groups of FGFs that are differentially expressed and suggest active stage-specific roles for FGF signaling during the fracture repair process. Developmental Dynamics 238:766-774, 2009. (C) 2009 Wiley-Liss, Inc.
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