期刊
DEVELOPMENTAL DYNAMICS
卷 239, 期 1, 页码 34-44出版社
WILEY-LISS
DOI: 10.1002/dvdy.22019
关键词
protein kinase; Wnt; beta-catenin; GSK3; CKI
资金
- CIHR [153320]
- NSERC [203545]
- NIH [GM076561]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076561] Funding Source: NIH RePORTER
The Wnt/beta-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Writ pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases. Developmental Dynamics 239:34-44, 2010. (C) 2009 Wiley-Liss, Inc.
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