期刊
DEVELOPMENTAL DYNAMICS
卷 238, 期 12, 页码 3266-3272出版社
WILEY
DOI: 10.1002/dvdy.22155
关键词
Muscleblind-like 1; alternative splicing, transforming growth factor beta; epithelial-mesenchymal transition; cardiac morphogenesis
资金
- March of Dimes
- American Heart Association
- National Institutes of Health
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL089376] Funding Source: NIH RePORTER
The development of the valves and septa of the heart depends on the formation and remodeling of endocardial cushions. Here, we report that the alternative splicing regulator muscleblind-like 1 (MBNL1) exhibits a regionally restricted pattern of expression in canal region endocardium and ventricular myocardium. during endocardial cushion development in chicken. Knockdown of MBNL1 in atrioventricular explants leads to a transforming growth factor V-dependent increase in epithelial-mesenchymal transition (EMT) of endocardial cells. This reveals a novel role for MBNL1 during embryonic development, and represents the first evidence that an alternative splicing regulator is a key player in endocardial cushion development. Developmental Dynamics 238:3266-3272, 2009. (C) 2009 Wiley-Liss, Inc.
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