期刊
DEVELOPMENTAL DYNAMICS
卷 238, 期 10, 页码 2680-2687出版社
WILEY
DOI: 10.1002/dvdy.22081
关键词
Btrc mutant mouse; retinal differentiation; amacrine cells; beta-TrCP
资金
- NIH [AI050831]
- NIH COBRE program of the National Center for Research Resources [P20 RR 15555]
- National Heart, Lung, and Blood Institute
Previous microarray analysis revealed beta-transducin repeat containing (Btrc) down-regulation in the retina of mouse embryos specifically lacking cholinergic amacrine cells (CACs) as a result of the absence of skeletal musculature and fetal ocular movements. To investigate the role of Btrc in the determination of retinal cell fate, the present study examined retinal morphology in Btrc(-/-) mouse fetuses. The Btrc(-/-) retina showed a normal number of cell layers and number of cells per layer with normal cell proliferation and apoptosis. However, there was a complete absence of CACs and a decrease in tyrosine hydroxylase-expressing amacrine cells. The population of other amacrine cell subtypes was normal, whereas that of the precursor cells was decreased. There was also a reduction in the number of retinal ganglion cells, whereas their progenitors were increased. These findings suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types. Developmental Dynamics 238.2680-2687, 2009. (c) 2009 Wiley-Liss, Inc.
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