期刊
DEVELOPMENTAL DYNAMICS
卷 237, 期 10, 页码 2693-2704出版社
WILEY
DOI: 10.1002/dvdy.21594
关键词
skeletogenesis; hematopoiesis; stem cell niche; cytokines; extracellular matrix
资金
- National Institute of Health [DK57904, AR053804-NRSA]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [F32AR053804] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK057904] Funding Source: NIH RePORTER
Disruption of collagen X function in hypertrophic cartilage undergoing endochondral ossification was previously linked to altered hematopoiesis in collagen X transgenic (Tg) and null (KO) mice (Jacenko et al., [2002] Am J Pathol 160:2019-2034). Mice displayed altered growth plates, diminished trabecular bone, and marrow hypoplasia with an aberrant lymphocyte profile throughout life. This study identifies altered B220(+), CD4(+), and CD8(+) lymphocyte numbers, as well as CD4(+)/fox3P(+) T regulatory cells in the collagen X mice. Additionally, diminished in vitro splenocyte responses to mitogens and an inability of mice to survive a challenge with Toxoplasma gondii, confirm impaired immune responses. In concert, ELISA and protein arrays identify aberrant levels of inflammatory, chemo-attractant, and matrix binding cytokines in collagen X mouse sera. These data link the disruption of collagen X function in the chondro-osseous junction to an altered hematopoietic stem cell niche in the marrow, resulting in impaired immune function. Developmental Dynamics 237:2693-2704, 2008. (C) 2008 Wiley-Liss, Inc.
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