期刊
DEVELOPMENTAL DYNAMICS
卷 237, 期 11, 页码 3280-3294出版社
WILEY-LISS
DOI: 10.1002/dvdy.21736
关键词
endothelial differentiation genes; Edg; lysophospbatidic acid; LPA; sphingosine-l-phosphate; S1P; G protein-coupled receptors; GPR23; GPR92; Gna13
Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (SIP) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P(1) to S1P(5) and LPA(1) to LPA(3)), LPA(4) (GPR23 /P2Y9), and LPA(5) (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis. Developmental Dynamics 237.3280-3294, 2008. (C) 2008 Wiley-Liss, Inc.
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