期刊
DEVELOPMENTAL CELL
卷 28, 期 2, 页码 174-188出版社
CELL PRESS
DOI: 10.1016/j.devcel.2013.12.010
关键词
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资金
- Swiss National Science Foundation [31003A_129957]
- European Research Council (EPIGENOME)
- European Cooperation in Science and Technology [BM1102]
- Swiss National Science Foundation (SNF) [31003A_129957] Funding Source: Swiss National Science Foundation (SNF)
In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramecium, somatic genome development from the germline genome accurately eliminates the bulk of typically gene-interrupting, noncoding DNA. We have discovered an sRNA class (internal eliminated sequence [IES] sRNAs [iesRNAs]), arising later during Paramecium development, which originates from and precisely delineates germline DNA (IESs) and complements the initial sRNAs (scan RNAs [scnRNAs]) in targeting DNA for elimination. We show that whole-genome duplications have facilitated successive differentiations of Paramecium Dicer-like proteins, leading to cooperation between Dcl2 and Dcl3 to produce scnRNAs and to the production of iesRNAs by Dcl5. These innovations highlight the ability of sRNA systems to acquire capabilities, including those in genome development and integrity.
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