期刊
DEVELOPMENTAL CELL
卷 31, 期 6, 页码 761-773出版社
CELL PRESS
DOI: 10.1016/j.devcel.2014.11.021
关键词
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资金
- Intramural Research Program of the NIH
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Biotechnology Information
- NIH [5R21HD066244-02, 5F31HD076558-02]
- Wellcome Trust [WT085521MA, WT082987MF]
Primary sex-determination switches evolve rapidly, but Doublesex (DSX)-related transcription factors (DMRTs) act downstream of these switches to control sexual development in most animal species. Drosophila dsx encodes female- and male-specific isoforms (DSXF and DSXM), but little is known about how dsx controls sexual development, whether DSXF and DSXM bind different targets, or how DSX proteins direct different outcomes in diverse tissues. We undertook genome-wide analyses to identify DSX targets using in vivo occupancy, binding site prediction, and evolutionary conservation. We find that DSXF and DSXM bind thousands of the same targets in multiple tissues in both sexes, yet these targets have sex- and tissue-specific functions. Interestingly, DSX targets show considerable overlap with targets identified for mouse DMRT1. DSX targets include transcription factors and signaling pathway components providing for direct and indirect regulation of sex- biased expression.
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