期刊
DEVELOPMENTAL CELL
卷 26, 期 3, 页码 250-265出版社
CELL PRESS
DOI: 10.1016/j.devcel.2013.07.005
关键词
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资金
- CNRS
- ANR [ANR-06-JCJC-0092]
- ARC postdoctoral fellowship
- FSER (Schlumberger)
- Ville de Paris
- Fondation BNP-Paribas
- Institut Pasteur
- equipe FRM2012
- Agence Nationale de la Recherche (ANR) [ANR-06-JCJC-0092] Funding Source: Agence Nationale de la Recherche (ANR)
Abscission is the last step of cytokinesis that physically separates the cytoplasm of sister cells. As the final stage of cell division, abscission is poorly characterized during animal development. Here, we show that Aurora B and Survivin regulate the number of germ cells in each Drosophila egg chamber by inhibiting abscission during differentiation. This inhibition is mediated by an Aurora B-dependent phosphorylation of Cyclin B, as a phosphomimic form of Cyclin B rescues premature abscission caused by a loss of function of Aurora B. We show that Cyclin B localizes at the cytokinesis bridge, where it promotes abscission. We propose that mutual inhibitions between Aurora B and Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst. Finally, we show that inhibitions of Aurora B and Cyclin-dependent kinase 1 activity in vertebrate cells also have opposite effects on the timing of abscission, suggesting a possible conservation of these mechanisms.
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