期刊
DEVELOPMENTAL CELL
卷 27, 期 1, 页码 60-71出版社
CELL PRESS
DOI: 10.1016/j.devcel.2013.08.004
关键词
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资金
- SNF-Forderungprofessur
- ETHZ
- University of Geneva
- Louis-Jeantet Foundation
- Bohringer Ingelheim
- Marie Curie Cancer Care
- BBSRC [BB/IO21353/1]
- BBSRC [BB/I021353/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I021353/1] Funding Source: researchfish
Kinetochores are the central force-generating machines that move chromosomes during cell division. It is generally assumed that kinetochores move in an autonomous manner. However, we reveal here that movements of neighboring sister-kinetochore pairs in metaphase are correlated in a distance-dependent manner. This correlation increases in the absence of kinetochore oscillations or stable end-on attachments. This suggests that periodic movements of bioriented chromosomes limit the correlated motion of nonsisters. Computer simulations show that these correlated movements can occur when elastic crosslinks are placed between the K-fibers of oscillating kinetochores. Strikingly, inhibition of the microtubule crosslinking motor kinesin-5 Eg5 leads to an increase in nonsister correlation and impairs periodic oscillations. These phenotypes are partially rescued by codepletion of the kinesin-12 Kif15, demonstrating a function for kinesin-5 and kinesin-1 2 motors in driving chromosome movements, possibly as part of a crosslinking structure that correlates the movements of nonsister kinetochores.
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