期刊
DEVELOPMENTAL CELL
卷 26, 期 6, 页码 604-615出版社
CELL PRESS
DOI: 10.1016/j.devcel.2013.08.014
关键词
-
资金
- Wellcome Trust [086451, 092096]
- Academy of Finland [135473, 138327]
- Cancer Research UK (CRUK) [C6946/A14492]
- Academy of Finland (AKA) [135473, 138327, 138327, 135473] Funding Source: Academy of Finland (AKA)
Controlling the position of the nucleus is vital for a number of cellular processes from yeast to humans. In Drosophila nurse cells, nuclear positioning is crucial during dumping, when nurse cells contract and expel their contents into the oocyte. We provide evidence that in nurse cells, continuous filopodia-like actin cables, growing from the plasma membrane and extending to the nucleus, achieve nuclear positioning. These actin cables move nuclei away from ring canals. When nurse cells contract, actin cables associate laterally with the nuclei, in some cases inducing nuclear turning so that actin cables become partially wound around the nuclei. Our data suggest that a perinuclear actin meshwork connects actin cables to nuclei via actin-crosslinking proteins such as the filamin Cheerio. We provide a revised model for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据