期刊
DEVELOPMENTAL CELL
卷 24, 期 2, 页码 133-143出版社
CELL PRESS
DOI: 10.1016/j.devcel.2012.12.010
关键词
-
资金
- National Basic Research Program of China [2011CB943901, 2011 CB943902]
- Nature Sciences foundation of China [31030049, 31271582]
- Strategic Priority Research Program of the Chinese Academy of Sciences Grant [XDA01010101]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-YW-R-240]
Homeostasis in adult tissues is maintained by resident stem cells and their progeny. Little is known about the regulation of tissue homeostasis by organ-organ interaction. Here we demonstrate that trachea-derived Decapentaplegic (Dpp), the main bone morphogenetic protein ligand in Drosophila, is essential for adult midgut homeostasis. We show that Dpp signaling is primarily activated in enterocytes (ECs). Depletion of Dpp signaling in ECs results in excess amounts of intestinal stem-cell-like cells and their progeny. Importantly, we find that Dpp is expressed specifically in tracheal cells that reach the intestinal cells through the visceral muscles. Depletion of dpp expression in tracheal cells phenocopies the Dpp loss-of-function defects in ECs. Our data demonstrate that the Drosophila trachea not only exchanges air for bodily needs but also produces a Dpp morphogen essential for neighboring tissue homeostasis. This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据