期刊
DEVELOPMENTAL CELL
卷 26, 期 5, 页码 441-454出版社
CELL PRESS
DOI: 10.1016/j.devcel.2013.08.020
关键词
-
资金
- Fondation Leducq Transatlantic Network of Excellence
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Special Program Molecular Clinical Oncology 5x1000 to AIRC-Gruppo Italiano Malattie Mieloproliferative
- European Community [ENDOSTEM-HEALTH-2009-241440, JUSTBRAIN-HEALTH-2009-241861]
- European Research Council (ERC)
- CARIPLO Foundation
- Structured International Post Doc Program
- European Community (ITN Vessels),
VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key role in the maintenance of vascular integrity. During embryo development, VE-cadherin is required for the organization of a stable vascular system, and in the adult it controls vascular permeability and inhibits unrestrained vascular growth. The mechanisms of action of VE-cadherin are complex and include reshaping and organization of the endothelial cell cytoskeleton and modulation of gene transcription. Here we review some of the most important pathways through which VE-cadherin modulates vascular homeostasis and discuss the emerging concepts in the overall biological role of this protein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据