期刊
DEVELOPMENTAL CELL
卷 22, 期 2, 页码 244-254出版社
CELL PRESS
DOI: 10.1016/j.devcel.2012.01.014
关键词
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资金
- Spanish Ministry of Science and Innovation (MICINN) [SAF2010-17555, RD06/0014/0038 (RECAVA), RD06/0010/1013 (TERCEL), FP7-ITN 215761 (NotchIT)]
- NIH [U01 HL100405, R01 HL095634]
- American Heart Association Jon Holden DeHaan Myogenesis Center
- WW Smith Endowed Chair
- Spain Fund for Cardiovascular Regenerative Medicine
- MICINN
- Pro-CNIC Foundation
The Notch pathway is a crucial cell-fate regulator in the developing heart. Attention in the past centered on Notch function in cardiomyocytes. However, recent advances demonstrate that region-specific endocardial Notch activity orchestrates the patterning and morphogenesis of cardiac chambers and valves through regulatory interaction with multiple myocardial and neural crest signals. Notch also regulates cardiomyocyte proliferation and differentiation during ventricular chamber development and is required for coronary vessel specification. Here, we review these data and highlight disease connections, including evidence that Notch-Hey-Bmp2 interplay impacts adult heart valve disease and that Notch contributes to cardiac arrhythmia and pre-excitation syndromes.
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