期刊
DEVELOPMENTAL CELL
卷 22, 期 4, 页码 871-878出版社
CELL PRESS
DOI: 10.1016/j.devcel.2012.01.020
关键词
-
资金
- HSFCSR
- OGSST
- Ontario Graduate Scholarship
- CIHR
Balancing progenitor cell self-renewal and differentiation is essential for brain development and is regulated by the activity of chromatin remodeling complexes. Nevertheless, linking chromatin changes to specific pathways that control cortical histogenesis remains a challenge. Here we identify a genetic interaction between the chromatin remodeler Snf2I and Foxg1, a key regulator of neurogenesis. Snf2I mutant mice exhibit forebrain hypercellularity arising from increased Foxg1 expression, increased progenitor cell expansion, and delayed differentiation. We demonstrate that Snf2I binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2I and Foxg1 function antagonistically to regulate brain size.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据