期刊
DEVELOPMENTAL CELL
卷 23, 期 5, 页码 995-1005出版社
CELL PRESS
DOI: 10.1016/j.devcel.2012.09.009
关键词
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资金
- Association Francaise contre les Myopathies
- Marie Curie Outgoing International Fellowship
- Pew Scholar Award
- National Institutes of Health [1-R01-GM061952, GM007127]
- Natural Science and Engineering Research Council of Canada
- Discovery Grant program
- Regroupement Quebecois pour lea Materiaux de Pointe
Vertebrate body segmentation is controlled by the segmentation clock, a molecular oscillator involving transcriptional oscillations of cyclic genes in presomitic mesoderm cells. The rapid and highly dynamic nature of this oscillating system has proved challenging for study at the single-cell level. We achieved visualization of clock activity with a cellular level of resolution in living embryos, allowing direct comparison of oscillations in neighbor cells. We provide direct evidence that presomitic mesoderm cells oscillate asynchronously in zebrafish Notch pathway mutants. By tracking oscillations in mitotic cells, we reveal that a robust cell-autonomous, Notch-independent mechanism resumes oscillations after mitosis. Finally, we find that cells preferentially divide at a certain oscillation phase, likely reducing the noise generated by cell division in cell synchrony and suggesting an intriguing relationship between the mitotic cycle and clock oscillation.
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