期刊
DEVELOPMENTAL CELL
卷 23, 期 5, 页码 1072-1080出版社
CELL PRESS
DOI: 10.1016/j.devcel.2012.09.020
关键词
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资金
- NIH [AI0149558, AI078087, AI098421, AI081803, GM097435]
- UK BBSRC
- School of Biological Sciences from the University of Edinburgh
- Medical Research Council [G0900740] Funding Source: researchfish
- MRC [G0900740] Funding Source: UKRI
Chromatin diminution is the programmed elimination of specific DNA sequences during development. It occurs in diverse species, but the function(s) of diminution and the specificity of sequence loss remain largely unknown. Diminution in the nematode Ascaris suum occurs during early embryonic cleavages and leads to the loss of germline genome sequences and the formation of a distinct genome in somatic cells. We found that similar to 43 Mb (similar to 13%) of genome sequence is eliminated in A. suum somatic cells, including similar to 12.7 Mb of unique sequence. The eliminated sequences and location of the DNA breaks are the same in all somatic lineages from a single individual and between different individuals. At least 685 genes are eliminated. These genes are preferentially expressed in the germline and during early embryogenesis. We propose that diminution is a mechanism of germline gene regulation that specifically removes a large number of genes involved in gametogenesis and early embryogenesis.
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