期刊
DEVELOPMENTAL CELL
卷 23, 期 6, 页码 1111-1120出版社
CELL PRESS
DOI: 10.1016/j.devcel.2012.10.008
关键词
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资金
- Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology
- CellNetworks Cluster of Excellence
- European Research Council
- [SFB488]
- [SFB887]
It is a challenge in developmental biology to understand how an embryo's genes, proteins, and cells function and interact to govern morphogenesis, cell fate specification, and patterning. These processes span very different spatial and temporal scales. Despite much progress, simultaneous observation of such vastly differing scales has been beyond the scope of conventional microscopy. Light sheet microscopy fills this gap and is increasingly used for long-term, high-speed recordings of large specimens with high contrast and up to subcellular spatial resolution. We provide an overview of applications of light sheet microscopy in developmental biology and discuss future perspectives in this field.
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