期刊
DEVELOPMENTAL CELL
卷 21, 期 4, 页码 642-654出版社
CELL PRESS
DOI: 10.1016/j.devcel.2011.09.004
关键词
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资金
- Israel Science Foundation
- Minerva Foundation
- Kirk Center for Childhood Cancer and Immunological Disorders
- Irvin Green Alzheimer's Research Fund
The hypothalamo-neurohypophyseal system (HNS) is the neurovascular structure through which the hypothalamic neuropeptides oxytocin and argininevasopressin exit the brain into the bloodstream, where they go on to affect peripheral physiology. Here, we investigate the molecular cues that regulate the neurovascular contact between hypothalamic axons and neurohypophyseal capillaries of the zebrafish. We developed a transgenic system in which both hypothalamic axons and neurohypophyseal vasculature can be analyzed in vivo. We identified the cellular organization of the zebrafish HNS as well as the dynamic processes that contribute to formation of the HNS neurovascular interface. We show that formation of this interface is regulated during development by local release of oxytocin, which affects endothelial morphogenesis. This cell communication process is essential for the establishment of a tight axovasal interface between the neurons and blood vessels of the HNS. We present a unique example of axons affecting endothelial morphogenesis through secretion of a neuropeptide.
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