期刊
DEVELOPMENTAL CELL
卷 21, 期 6, 页码 1014-1025出版社
CELL PRESS
DOI: 10.1016/j.devcel.2011.09.010
关键词
-
资金
- NIH [HD12304, HD068524]
- CCHMC Perinatal Institute
- NICHD [T32 HD07463]
- NRSA [F30AG040858]
- Lalor Foundation
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [23890045] Funding Source: KAKEN
An effective bidirectional communication between an implantation-competent blastocyst and the receptive uterus is a prerequisite for mammalian reproduction. The blastocyst will implant only when this molecular cross-talk is established. Here we show that the muscle segment homeobox gene (Msh) family members Msx1 and Msx2, which are two highly conserved genes critical for epithelial-mesenchymal interactions during development, also play crucial roles in embryo implantation. Loss of Msx1/Msx2 expression correlates with altered uterine luminal epithelial cell polarity and affects E-cadherin/beta-catenin complex formation through the control of Wnt5a expression. Application of Wnt5a in vitro compromised blastocyst invasion and trophoblast outgrowth on cultured uterine epithelial cells. The finding that Msx1/Msx2 genes are critical for conferring uterine receptivity and readiness to implantation could have clinical significance, because compromised uterine receptivity is a major cause of pregnancy failure in IVF programs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据