期刊
DEVELOPMENTAL CELL
卷 20, 期 6, 页码 775-787出版社
CELL PRESS
DOI: 10.1016/j.devcel.2011.04.018
关键词
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资金
- NICHD
- The University of Iowa, Department of Biology
- NIH [R37 NS033642, R01AR46207]
- March of Dimes [6-FY08-255]
- Canadian Cancer Society Research Institute (CCSRI)
- Canadian Institutes of Health Research (CIHR)
- Fonds de Recherche en Sante du Quebec (FRSQ)
- The University of Michigan Biological Sciences
- The Endowment for Basic Sciences
Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1). However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1, CDO, and BOC, as putative coreceptors for HH ligands. A central question is to what degree these coreceptors function similarly and what their collective requirement in HH signal transduction is. Here we provide evidence that GAS1, COO, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube. Specifically, we demonstrate two important roles for these molecules: an early role in cell fate specification of multiple neural progenitors and a later role in motor neuron progenitor maintenance. Most strikingly, genetic loss-of-function experiments indicate an obligatory requirement for GAS1, CDO, and BOC in HH pathway activity in multiple tissues.
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