期刊
DEVELOPMENTAL CELL
卷 20, 期 6, 页码 880-887出版社
CELL PRESS
DOI: 10.1016/j.devcel.2011.05.009
关键词
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资金
- NSF [DMS-0718604, DBI-0649833]
- NIH [P50 GM071508, RO1 GM078079, NS058465, R01-GM45248]
- MICINN [BFU2008-01875]
- AGAUR [2009SGR-1075]
- Sloan Foundation
- DuPont Foundation
- ICREA Funding Source: Custom
Developing tissues are patterned by coordinated activities of signaling systems, which can be integrated by a regulatory region of a gene that binds multiple transcription factors or by a transcription factor that is modified by multiple enzymes. Based on a combination of genetic and imaging experiments in the early Drosophila embryo, we describe a signal integration mechanism that cannot be reduced to a single gene regulatory element or a single transcription factor. This mechanism relies on an enzymatic network formed by mitogen-activated protein kinase (MAPK) and its substrates. Specifically, anteriorly localized MAPK substrates, such as Bicoid, antagonize MAPK-dependent down-regulation of Capicua, a repressor that is involved in gene regulation along the dorsoventral axis of the embryo. MAPK substrate competition provides a basis for ternary interaction of the anterior, dorsoventral, and terminal patterning systems. A mathematical model of this interaction can explain gene expression patterns with both anteroposterior and dorsoventral polarities.
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