期刊
DEVELOPMENTAL CELL
卷 17, 期 6, 页码 874-884出版社
CELL PRESS
DOI: 10.1016/j.devcel.2009.10.009
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资金
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Fondation pour la Recherche Medicale
- Leverhulme Trust Evolutionary Genetics of Human Nutrition Grant
- Wellcome Trust Functional Genomic Analysis of Aging Grant
- Max Planck Society
In metazoans, tissue growth relies on the availability of nutrients-stored internally or obtained from the environment-and the resulting activation of insulin/IGF signaling (IIS). In Drosophila, growth is mediated by seven Drosophila insulin-like peptides (Dilps), acting through a canonical IIS pathway. During the larval period, animals feed and Dilps produced by the brain couple nutrient uptake with systemic growth. We show here that, during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal. Expression of DILP6 during pupal development is controlled by the steroid hormone ecdysone. Remarkably, DILP6 expression is also induced upon starvation, and both its developmental and environmental expression require the Drosophila FoxO transcription factor. This study reveals a specific class of ILPs induced upon metabolic stress that promotes growth in conditions of nutritional deprivation or following developmentally induced cessation of feeding.
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