期刊
DEVELOPMENTAL CELL
卷 14, 期 4, 页码 570-581出版社
CELL PRESS
DOI: 10.1016/j.devcel.2008.03.003
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资金
- NCI NIH HHS [R01 CA057621, R01 CA057621-07, CA057621] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007731, HL-007731] Funding Source: Medline
- NIEHS NIH HHS [ES012801, U01 ES012801, U01 ES012801-05] Funding Source: Medline
Epithelial organs are built through the movement of groups of interconnected cells. We observed cells in elongating mammary ducts reorganize into a multilayered epithelium, migrate collectively, and rearrange dynamically, all without forming leading cellular extensions. Duct initiation required proliferation, Rac, and myosin light-chain kinase, whereas repolarization to a bilayer depended on Rho kinase. We observed that branching morphogenesis results from the active motility of both luminal and myoepithelial cells. Luminal epithelial cells advanced collectively, whereas myoepithelial cells appeared to restrain elongating ducts. Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth.
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