期刊
DEVELOPMENTAL CELL
卷 14, 期 4, 页码 474-479出版社
CELL PRESS
DOI: 10.1016/j.devcel.2008.03.015
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资金
- NCI NIH HHS [R21 CA133269-01, R21 CA133269] Funding Source: Medline
- NIGMS NIH HHS [R01 GM063045-08, R01 GM063045] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R21CA133269] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063045] Funding Source: NIH RePORTER
The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a wait anaphase signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.
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