期刊
DEVELOPMENTAL BIOLOGY
卷 442, 期 2, 页码 210-219出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2018.08.010
关键词
Dystroglycan; Axon; Optic chiasm; Retina; Basement membrane; Extracellular matrix
资金
- National Institutes of Health [R01-NS091027]
- Whitehall Foundation
- Medical Research Foundation of Oregon
- National Science Foundation Graduate Research Fellowship Program
- LaCroute Neurobiology of Disease Fellowship
In the developing visual system, retinal ganglion cell (RGC) axons project from the retina to several distal retinorecipient regions in the brain. Several molecules have been implicated in guiding RGC axons in vivo, but the role of extracellular matrix molecules in this process remains poorly understood. Dystroglycan is a laminin-binding transmembrane protein important for formation and maintenance of the extracellular matrix and basement membranes and has previously been implicated in axon guidance in the developing spinal cord. Using two genetic models of functional dystroglycan loss, we show that dystroglycan is necessary for correct sorting of contralateral and ipsilateral RGC axons at the optic chiasm. Mis-sorted axons still target retinorecipient brain regions and persist in adult mice, even after axon pruning is complete. Our results highlight the importance of the extracellular matrix for axon sorting at an intermediate choice point in the developing visual circuit.
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