期刊
DEVELOPMENTAL BIOLOGY
卷 371, 期 2, 页码 121-135出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2012.08.026
关键词
Craniofacial; Head skeleton; Pharynx; Jaw; Face; Dorsoventral; Middle ear; Endothelinl (Edn1); Bone Morphogenetic Protein (BMP); Jagged-Notch; Hand; Dlx; Msx; Gnathostome; Agnathan; Lamprey; Evolution
资金
- NSF Grant [IOS 0920751]
- NIH [R01DE018405]
- March of Dimes Grants
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0920751] Funding Source: National Science Foundation
Patterning of the vertebrate facial skeleton involves the progressive partitioning of neural-crest-derived skeletal precursors into distinct subpopulations along the anteroposterior (AP) and dorsoventral (DV) axes. Recent evidence suggests that complex interactions between multiple signaling pathways, in particular Endothelin-1 (Edn1), Bone Morphogenetic Protein (BMP), and Jagged-Notch, are needed to pattern skeletal precursors along the DV axis. Rather than directly determining the morphology of individual skeletal elements, these signals appear to act through several families of transcription factors, including Dlx, Msx, and Hand, to establish dynamic zones of skeletal differentiation. Provocatively, this patterning mechanism is largely conserved from mouse and zebrafish to the jawless vertebrate, lamprey. This implies that the diversification of the vertebrate facial skeleton, including the evolution of the jaw, was driven largely by modifications downstream of a conversed pharyngeal DV patterning program. (c) 2012 Elsevier Inc. All rights reserved.
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