4.4 Article

Cdkn1c drives muscle differentiation through a positive feedback loop with Myod

期刊

DEVELOPMENTAL BIOLOGY
卷 350, 期 2, 页码 464-475

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2010.12.010

关键词

Muscle; Cdkn1c; Zebrafish; Hedgehog; Myod; Myog; p57kip2

资金

  1. MRC
  2. MRC [G1001029, G0300213] Funding Source: UKRI
  3. Medical Research Council [G0300213, G1001029] Funding Source: researchfish

向作者/读者索取更多资源

Differentiation often requires conversion of analogue signals to a stable binary output through positive feedback. Hedgehog (Hh) signalling promotes myogenesis in the vertebrate somite, in part by raising the activity of muscle regulatory factors (MRFs) of the Myod family above a threshold. Hh is known to enhance MRF expression. Here we show that Hh is also essential at a second step that increases Myod protein activity, permitting it to promote Myogenin expression. Hh acts by inducing expression of cdkn1c (p57(Kip2)) in slow muscle precursor cells, but neither Hh nor Cdkn1c is required for their cell cycle exit. Cdkn1c co-operates with Myod to drive differentiation of several early zebrafish muscle fibre types. Myod in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据