期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 782, 期 -, 页码 111-115出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2015.01.030
关键词
Coordination complexes; Reactive oxygen species; Kynurenines; Mass spectrometry; Degenerative diseases; Neurotoxin
资金
- Austrian Science Fund (FWF) [P24630-B21]
- Austrian Science Fund (FWF) [P24630] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 24630] Funding Source: researchfish
The tryptophan metabolite, quinolinic (2,3-pyridinedicarboxylic) acid, is known as an endogenous neurotoxin. Quinolinic acid can form coordination complexes with iron or copper. The effects of quinolinic acid on reactive oxygen species production in the presence of iron or copper were explored by a combination of chemical assays, classical site-specific and ascorbic acid-free variants of the deoxyribose degradation assay, and mass spectrometry (ESI-MS). Quinolinic acid showed evident antioxidant activity in chemical assays, but the effect was more pronounced in the presence of copper as transition metal catalyst than in presence of iron. Nano-ESI-MS confirmed the ability of quinolinic acid to form coordination complexes with iron(II) or copper(II) and quinolinic acid stability against oxidative attack by hydroxyl radicals. The results illustrate a highly milieu-dependent quinolinic acid chemistry when it enters reactions as competitive ligand. (C) 2015 The Authors. Published by Elsevier B.V.
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