期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 796, 期 -, 页码 59-64出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2015.02.004
关键词
Arene ruthenium complexes; Bioorganometallic chemistry; Metal-based drugs; Metallarectangles; Anticancer activity
资金
- Secretariat d'Etat a l'education et a la recherche
- Swiss Confederation
A series of arene ruthenium metalla-rectangles of general formula [(eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-N boolean AND N)(2)](CF3SO3)(4) was prepared from the embelin-derived metalla-clip (eta(6)-p-cymene)(2)Ru-2(mu(4)-embelin) Cl-2 (1), silver triflate and several linear ditopic N-ligands (N boolean AND N); pyrazine (prz), 4,4'-bipyridine (bpy), 1,2-bis(4-pyridyl)ethylene (bpe), 4,4'-azopyridine (azp) and di(pyridin-4-yl)oxalamide (bpo). The anti-proliferative activity of these multinuclear arene ruthenium metalla-rectangles was evaluated in vitro on the human ovarian cancer cells A2780 and A2780cisR and on the noncancerous cell line HEK-293. Among these complexes, two rectangles, [(eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-bpy)(2)](CF3SO3)(4) and [(eta(6)-p-cymene) Ru-4(4)(mu(4)-embelin)(2)(mu(2)-bpo)(2)](CF3SO3)(4), display excellent activity and selectivity for cancer cells. (C) 2015 Elsevier B.V. All rights reserved.
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