期刊
DEVELOPMENTAL BIOLOGY
卷 337, 期 1, 页码 124-133出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2009.10.021
关键词
Mammary gland; Mast cell; Branching morphogenesis; Development; Terminal end bud
资金
- National Cancer Institute
- National Institute of Environmental Health Sciences [CA057621, ES012801]
- DOD-CMDRP [W81XWH-05-1-0272]
- NATIONAL CANCER INSTITUTE [R01CA057621] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [U01ES012801] Funding Source: NIH RePORTER
The stromal microenvironment regulates mammary gland branching morphogenesis. We have observed that mast cells are present in the mammary gland throughout its postnatal development and, in particular, are found around the terminal end buds and ductal epithelium of the pubertal gland. Mast cells contribute to allergy, inflammatory diseases, and cancer development but have not been implicated in normal development. Genetic and pharmacological disruption of mast cell function in the mammary gland revealed that mast cells are involved in rapid proliferation and normal duct branching during puberty. and this effect is independent of macrophage recruitment, which also regulates mammary gland development. For mast cells to exert their effects on normal morphogenesis required activation of their serine proteases and degranulation. Our observations reveal a novel role for mast cells during normal pubertal development in the mammary gland. (C) 2009 Elsevier Inc. All rights reserved.
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