期刊
DEVELOPMENTAL BIOLOGY
卷 339, 期 1, 页码 65-77出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2009.12.016
关键词
Jun N-terminal kinase; Fos; Jun; AP-1; Axonal morphogenesis; Neurodegeneration; Neural development; Drosophila
资金
- Wellcome Trust [078045]
- Medical Research Council (MRC)
- MRC [G0901899] Funding Source: UKRI
- Medical Research Council [G0901899] Funding Source: researchfish
Signaling proteins often control multiple aspects of cell morphogenesis. Yet the mechanisms that govern their pleiotropic behavior are often unclear. Here we show activity levels and timing mechanisms determine distinct aspects of Jun N-terminal kinase (JNK) pathway dependent axonal morphogenesis in Drosophila mushroom body (MB) neurons. In the complete absence of Drosophila JNK (Basket), MB axons fail to stabilize, leading to their subsequent degeneration. However, with a partial loss of Basket (Bsk), or of one of the upstream JNK kinases, Hemipterous or Mkk4, these axons overextend. This suggests that Bsk activity prevents axons from destabilizing, resulting in degeneration and overextension beyond their terminal targets. These distinct phenotypes require different threshold activities involving the convergent action of two distinct JNK kinases. We show that sustained Bsk signals are essential throughout development and act additively but are dispensable at adulthood. We also suggest that graded Bsk inputs are translated into AP-1 transcriptional outputs consisting of Fos and Jun proteins. (C) 2009 Elsevier Inc. All rights reserved.
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