期刊
DEVELOPMENTAL BIOLOGY
卷 335, 期 1, 页码 43-65出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2009.08.012
关键词
Forebrain; Rostrocaudal patterning; Dorsoventral patterning; Fate map; Fate specification; Gastrulation; Regionalization; Neurulation; Telencephalic field; Eye field
资金
- Spanish Ministry of Science and Innovation [BFU2005-09378-C02-01, BFU2008-04156, BFU2006-15330-C02-02]
We correlated available fate maps for the avian neural plate at stages HH4 and HH8 with the progress of local molecular specification, aiming to determine when the molecular specification maps of the primary longitudinal and transversal domains of the anterior forebrain agree with the fate mapped data. To this end, we examined selected gene expression patterns as they normally evolved in whole mounts and sections between HH4 and HH8 (or HH10/11 in some cases), performed novel fate-mapping experiments within the anterior forebrain at HH4 and examined the results at HH8, and correlated grafts with expression of selected gene markers. The data provided new details to the HH4 fate map, and disclosed some genes (e.g., Six3 and Ganf) whose expression domains initially are very extensive and subsequently retract rostralwards. Apart from anteroposterior dynamics, some genes soon became clownregulated at the prospective forebrain floor plate, or allowed to identify an early roof plate domain (dorsoventral pattern). Peculiarities of the telencephalon (initial specification and differentiation of pallium versus subpallium) are con tern plated. The basic anterior forebrain subdivisions seem to acquire correlated specification and fate mapping patterns around stage HH8. (C) 2009 Elsevier Inc. All rights reserved.
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