期刊
DEVELOPMENTAL BIOLOGY
卷 331, 期 2, 页码 129-139出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2009.04.028
关键词
Epithelial morphogenesis; Drosophila melanogaster oogenesis; Mechanics; Morphometric analysis; Computational modeling
资金
- UC Berkeley start-LIP funds
- Regents' Junior Faculty Fellowship
- National Science Foundation [CBET0829205]
- NIH [R01 GM068675]
- Burroughs Welcome Trust
- National Science Foundation Graduate Student Fellowship
- National Institutes of Health NRSA Training [5 T32 HG00047]
- Jane Coffin Childs Memorial Foundation
The process of epithelial morphogenesis is ubiquitous in animal development, but much remains to be learned about the mechanisms that shape epithelial tissues. The follicle cell (FC) epithelium encapsulating the growing germline of Drosophila is an excellent system to study fundamental elements of epithelial development. During stages 8 to 10 of oogenesis, the FC epithelium transitions between simple geometries-cuboidal, columnar and squamous-and redistributes cell populations in processes described as posterior migration, squamous cell flattening and main body cell columnarization. Here we have carried out a quantitative morphometric analysis of these Poorly understood events in order to establish the parameters of and delimit the potential processes that regulate the transitions. Our results compel a striking revision of accepted views of these phenomena, by showing that posterior migration does not involve FC movements, that there is no role for columnar cell apical constriction in FC morphogenesis, and that squamous cell flattening may be a compliant response to germline growth. We utilize mechanical modeling involving finite element computational technologies to demonstrate that time-varying viscoelastic properties and growth are sufficient to account for the bulk of the FC morphogenetic changes. (C) 2009 Published by Elsevier Inc.
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